On May 21, 2004, for Dinner for Five season 3, episode 7, she joined Jon Favreau, Stephen Dorff, Luis Guzmán, and Barry Pepper. Esposito has made television appearances on the series Law & Order: SVU, Rescue Me, and Mercy. She was a regular cast member on Related and Samantha Who?. Esposito joined the cast of the CBS drama Blue Bloods in 2010, playing the role of Detective Jackie Curatola, the partner of Detective Danny Reagan (played by Donnie Wahlberg). In the third season, Esposito was diagnosed with celiac disease, and after collapsing on set, Esposito informed CBS that her condition would limit her availability to work on the series. Rather than work around her limited schedule, Blue Bloods producers chose to write her character out of the series in 2012.