Jovovich gained attention for her role in the 1991 romance film Return to the Blue Lagoon, as she was then only 15. She was considered to have a breakthrough with her role in the 1997 French science-fiction film The Fifth Element, written and directed by Luc Besson. She and Besson married that year, but soon divorced. She starred as the heroine and martyr in Besson's The Messenger: The Story of Joan of Arc (1999). Between 2002 and 2016, Jovovich portrayed Alice in the science fiction horror film franchise Resident Evil, which became the highest-grossing film series to be based on video games.