Doherty's career afterward consisted primarily of made-for-TV movies, though she also had a lead role in Kevin Smith's 1995 film Mallrats and later cameoed in Jay and Silent Bob Strike Back. In 1998, Spelling again cast her in another of his television series, Charmed, in which she played lead character Prue Halliwell, the oldest of three sisters who are witches. Doherty also directed a few episodes for the series during the second and third seasons. Doherty left the show in 2001 at the end of the third season, resulting in her character's death. Reportedly, the reason for her departure was because of on-set and off-set tensions between Doherty and co-star Alyssa Milano. Doherty was also twice nominated, in 1999 and 2000, for the Saturn Award, Best Genre TV Actress, for her performance in Charmed. In 2004, E! placed Doherty at number 10 on their list of the 50 Most Wicked Women of Prime Time. In 2007, AOL named Prue Halliwell the 10th greatest witch in television history.